Progressive familial intrahepatic cholestasis type 2 (PIFC2) is a rare autosomal recessive liver disease. This article presents a 5-year-old girl with PIFIC2 who developed both vitiligo and psoriasis as co-localization. This coexistence of skin disorders may represent a new association with the genetic disease. No reports of this possible association have been previously published. The article overview relationships among Vitiligo, Psoriasis and Liver cholestasis.