Current Pediatric Research

Introduction: Sepsis induced AKI is reversible increase in serum creatinine levels or nitrogen metabolism products and the inability of the kidneys to regulate fluid and electrolytes to a state of body homeostasis caused by sepsis. This study aimed to find out relationship between sepsis-induced AKI and shock and length of stay in Pediatric Intensive Care Unit (PICU).

Methods: This prospective cohort study was conducted in PICU from November 2017 to October 2018. A total of 90 sepsis patients were included. The diagnostic of septic shock based on International Pediatric Sepsis Consensus 2015. Kidney function examination and urine production every 8 hours was done to determine whether or not Acute Kidney Injury present. Patient were observed until the outcome occurred; either septic patient become shock or not and how long they were treated in PICU.

Results: Result of 90 sepsis patients, 36 patients (40%) become sepsis-induced AKI. Chi Square analysis found significant differences in the incidence of shock in sepsis-induced AKI patient with p=0.00 with OR 4.37, 95% CI 1,689 - 11.33. Sepsis patient with AKI will undergo longer treatment in PICU if compared to sepsis patients without AKI. However, Mann-Whitney test showed not significant (p=0.25).

Conclusion: Incidence of sepsis-induced AKI in this cohort of children was 40%, and shock severity in patients with sepsis induced-AKI was higher than those with sepsis without AKI, and there was no difference in length of stay between sepsis patients with AKI and without AKI.

Author(s): Idham Jaya Ganda*, Karjana, Dasril Daud

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