Objective: To evaluate the using of nebulized 3% hypertonic saline as a treatment to hospitalized infants with bronchiolitis in Karbala providence. Methods: A total of 161 patients (age mean, 6.29 months) with bronchiolitis were studied. Patients (83) were randomized to receive, repeated doses (4 times/day) of nebulized 3% hypertonic saline and a control group (78) treated with conventional therapy. Staying period at hospital is the principle measuring of the results. Results: LOS of 3.38 days was determined in patient group, while 4.67 days in the control group with reduction of 27.8% (P=0.001). Treatment with hypertonic saline was sufficiently tolerated with no adverse effects. Conclusions: application of nebulized 3% hypertonic saline is an effective with low cost for patients hospitalized with moderately severe bronchiolitis.